Fig. 6.
Involvement of thromboxane in Up4A-induced relaxation. Shown are concentration responses to Up4A (10−9–10−5 M) in the presence and absence of 10 μM of the thromboxane synthase inhibitor ozagrel in porcine coronary small arteries (normal (n = 5, panel a); metabolic derangement (n = 4, panel c)), as well as in the presence of 100 μM of the NOS inhibitor LNAME (normal (n = 6, panel b); metabolic derangement (n = 7, panel d)). Values are mean ± SEM. *P < 0.05 effect of ozagrel vs. corresponding control