Figure 7.

Quinidine. Changes to APD90 and triangulation relative to control from application of 1 and 10 μM quinidine during 1 and 2 Hz pacing. In each panel, response is shown for (left to right): human ventricular trabeculae, populations of models using drug effects calculated using data from Crumb et al. from Crumb et al. with I_Kr replaced by the Li et al. I_Kr model; from Kramer et al.; and from Kramer et al. with I_Kr replaced by the Li et al. I_Kr model. Dots indicate results from individual trabeculae and models, crosses show the result from the baseline ORd model. Red symbols indicate simulations and experiments where repolarization abnormalities occurred.