Table 1.
Clinical features of each group.
| Responsive (n = 18) | Unresponsive (n = 15) | Control (n = 10) | P value | |
|---|---|---|---|---|
| Age (years) | 42.83 ± 12.28 | 44.33 ± 10.79 | 45.70 ± 13.66 | 0.83 |
| Female (n, %) | 11 (61.1%) | 8 (53.3%) | 6 (60.0%) | 0.95 |
| Smoking history | 4 (22.2%) | 3 (20%) | 2 (20%) | 0.99 |
| Alcohol intake | 2 (11.1%) | 1 (6.7%) | 1 (10%) | 0.91 |
| BMI | 22.75 ± 2.11 | 24.57 ± 3.88 | 22.01 ± 1.27 | 0.06 |
| SBP (mmHg) | 133.11 ± 17.10 | 131.40 ± 17.15 | 132.30 ± 15.79 | 0.96 |
| DBP (mmHg) | 77.56 ± 10.22 | 83.40 ± 9.46 | 80.70 ± 10.76 | 0.26 |
| ALT (U/L) | 15.67 ± 7.74 | 20.56 ± 14.41 | 18.20 ± 5.16 | 0.40 |
| AST (U/L) | 20.39 ± 7.95 | 21.25 ± 8.03 | 21.90 ± 6.15 | 0.88 |
| BUN (mmol/L) | 4.70 ± 1.49 | 3.95 ± 0.96 | 4.53 ± 1.12 | 0.22 |
| Cr (μmol/L) | 55.89 ± 22.78 | 44.27 ± 15.46 | 56.30 ± 5.89 | 0.13 |
| TG (mmol/L) | 1.39 ± 0.70 | 1.50 ± 0.74 | 1.75 ± 0.69 | 0.48 |
| TC (mmol/L) | 4.85 ± 1.19 | 5.15 ± 1.49 | 4.69 ± 1.33 | 0.72 |
| HDL (mmol/L) | 1.24 ± 0.47 | 1.20 ± 0.37 | 1.10 ± 0.28 | 0.70 |
| LDL (mmol/L) | 2.86 ± 0.69 | 3.23 ± 1.11 | 2.81 ± 1.00 | 0.52 |
| FT3 (pg/mL) | 5.75 ± 6.31 | 4.23 ± 1.77 | 2.99 ± 0.39 | 0.25 |
| FT4 (ng/dL) | 1.62 ± 1.17 | 1.43 ± 0.54 | 1.15 ± 0.16 | 0.36 |
| TSH (mUI/L) | 0.468 (0.004–2.465) | 0.070 (0.004–1.15) | 2.330 (1.304–3.05) | 0.02∗ |
| TRAb (UI/L) | 12.75 (5.78–27.20) | 12.75 (5.59–22.09) | 0.580 (0.320–0.650) | <0.001∗∗ |
| Hyperthyroidism duration (months) | 14 (7.25–25.5) | 22 (12–42) | — | 0.49 |
| GO duration (months) | 8.0 (3–12.25) | 9.5 (4.0–12.5) | — | 0.66 |
| Antithyroid treatments | ||||
| Antithyroid drug | 6 (33.3%) | 7 (46.7%) | — | 0.44 |
| Radioiodine | 9 (50.0%) | 6 (40.0%) | — | 0.57 |
| Thyroidectomy | 3 (16.7%) | 2 (13.3%) | — | 0.79 |
| CAS | 4.56 ± 1.10 | 4.27 ± 1.03 | — | 0.45 |
| Lid width (mm) | 11.06 ± 1.12 | 10.67 ± 1.02 | 8.50 ± 0.86 | <0.001∗∗ |
| Visual acuity | 0.80 ± 0.15 | 0.83 ± 0.18 | 0.99 ± 0.17 | 0.02∗ |
| Diplopia | 0.02∗ | |||
| Absent | 6 (33.3%) | 4 (26.7%) | 10 (100%) | |
| Intermittent | 5 (27.8%) | 5 (33.3%) | 0 | |
| Inconstant | 4 (22.2%) | 4 (26.7%) | 0 | |
| Constant | 3 (16.7%) | 2 (13.3%) | 0 |
∗ P < 0.05; ∗∗P < 0.001. TSH: responsive group versus unresponsive group, P = 0.722. TRAb: responsive group versus unresponsive group, P = 0.874. Lid width: responsive group versus unresponsive group, P = 0.288. Visual acuity: responsive group versus unresponsive group, P = 0.558. Diplopia: responsive group versus unresponsive group, P = 0.954.