Table 1. Ethanol-induced excitation of midbrain DA neurons from adolescent drinkers.

The values presented are the mean ± SEM of percentage change in firing rate in response to 10, 20, and 50 mM EtOH. The number of cells for each condition is displayed in parenthesis. Two tailed t-tests were used to compare the properties of VTA and SN DA neurons from naïve and experienced mice; p < 0.05 was considered significant (italicized values).

	VTA DA neurons			Medial VTA DA			Lateral VTA DA			SN DA neurons
	Naïve	EtOH	p value	Naïve	EtOH	p value	Naïve	EtOH	p value	Naïve (n = 11)	EtOH (n = 12)	p value
Baseline FR	3.0 ± 0.4 (42)	3.0 ± 0.2 (41)	0.96	3.3 ± 0.6 (21)	3.0 ± 0.4 (24)	0.7	2.3 ± 0.4 (18)	3.0 ± 0.4 (15)	0.23	2.6 ± 0.2	3.0 ± 0.2	0.3
ISI CV	0.13 ± 0.01 (42)	0.16 ± 0.02 (41)	0.13	0.19 ± 0.03 (21)	0.17 ± 0.01 (24)	0.4	0.12 ± 0.01 (18)	0.10 ± 0.01 (15)	0.3	0.064 ± 0.01	0.072 ± 0.01	0.6
10 mM	−0.4 ±2.9 (23)	9.5 ± 4.0 (27)	0.017	−3.4 ±2.9 (14)	7.7 ± 3.1 (16)	0.016	4.7 ± 5.2 (9)	10.2 ± 4.7 (9)	0.44	−2.2 ± 4.3	3.9 ± 1.2	0.17
20 mM	4.3 ± 2.6 (42)	18.9 ± 4.1 (41)	0.003	3.5 ± 2.9 (21)	19.1 ± 3.3 (24)	0.0012	2.0 ± 4.2 (18)	10.7 ± 4.9 (15)	0.19	4.6 ± 6.5	4.7 ± 2.4	0.98
50 mM	12.2 ± 3.5 (41)	26.5 ± 3.5 (41)	0.0049	10.1 ± 4.1 (21)	33.1 ± 4.3 (24)	0.0004	16.8 ± 6.4 (18)	16.6 ± 6.4 (15)	0.98	−4.3 ± 10.6	8.3 ± 4.3	0.27