Table 3.
Association of the 15Phe variant with IBS
| CTRL | IBS |
IBS-C |
IBS-D |
IBS-M |
IBS-D/M |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF | AF | p Value | OR | AF | p Value | OR | AF | p Value | OR | AF | p Value | OR | AF | p Value | OR | |
| Case–control | 0.264 | 0.306 | 0.0030* | 1.26 | 0.279 | 0.42 | 1.09 | 0.312 | 0.0082 | 1.30 | 0.329 | 0.0026* | 1.41 | 0.319 | 0.00051* | 1.34 |
| PopCol | 0.29 | 0.417 | 0.045 | 1.89 | 0.400 | 0.45 | 1.72 | 0.409 | 0.20 | 1.88 | 0.556 | 0.017 | 3.81 | 0.475 | 0.013 | 2.50 |
| Combined | 0.268 | 0.309 | 0.0013* | 1.27 | 0.281 | 0.39 | 1.10 | 0.314 | 0.0052 | 1.30 | 0.336 | 0.00057* | 1.46 | 0.323 | 0.00012* | 1.36 |
*p Value significant after Bonferroni correction for multiple comparisons (N=15), considering five traits (IBS, IBS-C, IBD-D, IBS-M and IBS-D/M) in three datasets (case–control cohorts, PopCol and both combined). Significant p Values (<0.05) highlighted in bold italics.
AF, 15Phe allele frequency; CTRL, controls; IBS-C, constipation-predominant IBS; IBS-D, diarrhoea-predominant IBS; IBS-D/M, IBS-D+IBS-M; IBS-M, IBS mixed phenotype; p Value, p Value from logistic regression adjusted for sex and batch (centre).