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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Neuropharmacology. 2017 Jun 21;123:420–432. doi: 10.1016/j.neuropharm.2017.06.019

Fig. 2. The DOR2 agonist deltorphin II inhibits some and excites other VTA neurons.

Fig. 2

Summary data showing the time course of deltorphin II induced hyperpolarizations (A) and depolarizations (B) in quiescent VTA neurons. Across all neurons, deltorphin II induced depolarizations tended to be followed by more rapid and complete reversal during washout than hyperpolarizations. Example recording (C) showing that 100 nM of the DOR selective antagonist TIPP-Ψ completely blocked the response to deltorphin II in VTA neurons. (D) Summary data showing that in control neurons reapplication of deltorphin II causes a second response of equal magnitude to the first response (right), however when the second deltorphin II application is performed in the presence of TIPP-Ψ (100 nM), the deltorphin II response is eliminated (right). Circles show individual neurons, grey bars indicate means. ****p ≤ 0.0001.