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. 2017 Aug 21;8:298. doi: 10.1038/s41467-017-00129-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Global transcription analysis suggests that H1152 treatment upregulated genes involved in mature pancreatic beta cell function. a Heatmap and hierarchical clustering of transcriptional profiling in INS ^GFP/W HES3-derived INS-GFP⁺ cells treated with H1152 compared to DMSO treated cells. Fetal and adult primary human beta cells were used as controls (GPL11154). b Pathway enrichment analysis on up-regulated or down-regulated genes in INS ^w/GFP HES3-derived INS-GFP⁺ cells treated with H1152 and adult human islets. c Heatmap of genes in the upregulated pathways, including insulin secretion and type 2 diabetes mellitus. d Heatmap of the genes in the downregulated pathways, including focal adherent and cell cycle. e GSEA of DMSO-treated, H1152-treated INS-GFP⁺ cells and fetal and adult human primary beta cells. The dataset are the gene expression level of DMSO-treated or H1152-treated INS-GFP⁺ cells. The adult beta gene set includes the genes that are >50-fold higher expressed in adult beta cells compared to fetal beta cells. The fetal beta gene set includes the genes that are >50-fold higher expressed in fetal beta cells compared to adult beta cells