Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 21;8:304. doi: 10.1038/s41467-017-00379-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Selectivity measurements in optimized DNA sequences. a Schematics of the design of an optimized sequence S₄ for selectivity measurements of ligands that bind or recognize 4 bps or less. S₄ includes all tetranucleotide combinations (K = 4). b Free energy landscape of S₄ sequence, containing 170 bps, obtained by Monte Carlo minimization of the roughness of the unzipping free energy landscape (Methods section). c Distribution of blockage positions obtained applying the FC protocol with hairpin H_s4 in presence of Echinomycin (number of beads = 182). Error bars are inversely proportional to the square root of the number of points for each bin. d The probability of observing a blockage at each possible dinucleotide step obtained from the results presented in c. The inset shows the probability of observing a blocking event at XCGY positions with X, Y = A,T,C,G. Error bars are inversely proportional to the square root of the number of points for each bin