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Inhibition profile of periodontopathic bacterial DPP4a
| Inhibitor | Concn (mM) | Residual activity (%) |
||
|---|---|---|---|---|
| PgDPP4 | TfDPP4 | PiDPP4 | ||
| P32/98 | 0.25 | 0.3 | 0.2 | 0.5 |
| Sitagliptin | 0.25 | 1.6 | 1.6 | 7.5 |
| Vildagliptin | 0.25 | 0 | 0.3 | 27.3 |
| PMSF | 1 | 52.3 | 71.2 | 40.8 |
| EDTA | 1 | 102.0 | 103.6 | 117.0 |
| Leupeptin | 0.1 | 104.3 | 102.4 | 94.4 |
The specific activities of PgDPP4, TfDPP4, and PiDPP4 against Gly-Pro-MCA were 0.93 ± 0.02, 0.67 ± 0.01, and 0.44 ± 0.01 U/mg of protein, respectively.
