FIG 5.

DC vaccines transduced with the dnSHP adenoviral construct and loaded with the recombinant Tc24 protein improve cardiac pathology. (A to E) Representative endpoint cardiac H&E histopathology reveals amastigote nest formation in mice from all groups except the ones treated with DCs loaded with the vector and protein. Images are shown at a ×100 magnification. Bar = 20 μm. (F to J) Representative H&E-stained images of the amastigote nests in cardiac tissues of each group of mice. Images are shown at a ×400 magnification. Bar = 5 μm. (K to O) Representative Masson's trichrome-stained images showing the extent of cardiac inflammatory fibrosis among mice of each treated group. Images are shown at a ×100 magnification. Bar = 20 μm.