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. 2015 Mar 2;31(3):351–356. doi: 10.1007/s12264-014-1511-7

Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development

Shengjie Feng 1,2, Zhuohao He 1,2, Hongyu Li 1,2, Yizheng Wang 1,✉
PMCID: PMC5563685  PMID: 25732528

Abstract

The spatial patterns of dendritic structures diverge in different types of neurons as adaptations to their unique functions. Although different intracellular mechanisms underlying dendritic morphogenesis have been suggested, it is evident that the elevation in intracellular Ca2+ levels plays a major role in the process. Canonical transient receptor potential (TRPC) channels, known to be non-selective Ca2+-permeable cation channels, act as environmental detectors to sense and transduce extracellular signals into different intracellular responses, including the regulation of dendritic growth, via Ca2+ influx. Here, we review recent advances in the understanding of Ca2+ signaling, especially signals mediated by Ca2+ influx via TRPC channels, and the underlying molecular events in dendritic development.

Keywords: dendrite, calcium, TRPC, neurotrophin

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