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Cryo-EM structure and working module of the mechanosensitive Piezo1 channel (provided by Dr. Bailong Xiao, Tsinghua University). A. The three-bladed, propeller-like cryo-EM structure. B. Illustration of the separable mechanotransduction and pore modules in either a topological (left panel) or a structural model (right panel). C. A structural model of the pore module with key residues highlighted.
