Fig. 1.
Intra-hippocampal injection of Aβ1–42 and Aβ31–35, but not Aβ35–31, impaired spatial learning and memory in rats. A, B, Plots and histograms comparing the effects of 2 nmol of the different Aβ fragments on escape latency and percentage swimming time in the target quadrant. Aβ1–42 and Aβ31–35 almost equally increased the escape latency on training days 2–5 (aa P < 0.01 compared with control group). C, D, Plots and histograms showing that Aβ31–35 dose-dependently suppressed learning and memory (bb P < 0.01 compared with 2.0 nmol Aβ31–35 group; c P < 0.05, cc P < 0.01 compared with 10.0 nmol Aβ31–35 group; **P < 0.01). Each point and column represents the mean ± SEM. E, Representative swimming tracks in probe trials on day 6.