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. 2017 Aug 9;284(1860):20170799. doi: 10.1098/rspb.2017.0799

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© 2017 The Author(s)

Published by the Royal Society. All rights reserved.

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Figure 4. — The influence of annual supplementation of gene-drive carriers on simulated mouse populations assuming the ‘daughterless’ strategy causing heterozygotic XX sterility, and a starting population size of 50 000 individuals. (a) Mean population trajectories for annual supplements of (i) 250 individuals and (ii) 1000 individuals. Confidence intervals are omitted to improve clarity. (b) Mean time to eradication (±95% CIs) as a function of annual supplement size assuming an NHEJ probability of 0.02 and three gRNAs.