Figure 6.
The impact of the probability of NHEJ (PN) and existing polymorphic resistance (PR) on the probability of successful mouse eradication (Perad) under the homozygotic XX sterility gene-drive strategy. The results shown assume an island carrying capacity of 50 000 mice, 100 gene-drive carriers used for inoculation, simultaneous gRNA expression and (a–c) two, three or four gRNAs. The plotted probabilities are derived from a binomial spatial spline fitted to the sensitivity-analysis output separately for each panel.