Skip to main content
. 2016 May 9;32(6):523–530. doi: 10.1007/s12264-016-0031-z

Fig. 1.

Fig. 1

Agmatine attenuated the naloxone-induced elevation of hippocampal extracellular glutamate in chronic morphine-treated rats. A Effect of acute administration of morphine, agmatine, or naloxone on dialysate glutamate levels in the hippocampal CA1 region (n = 9; *P < 0.05; ***P < 0.001 vs baseline; two-way ANOVA for repeat measures followed by Bonferroni test). Nal naloxone, Mor morphine, Agm agmatine. B Effect of agmatine on the elevation of hippocampal glutamate levels after naloxone injection in chronic morphine-treated rats (n = 5; *P < 0.05 vs Con group, # P < 0.05 vs Mor group; two-way ANOVA for repeat measures followed by Bonferroni test). Con control, Mor morphine, Agm + Mor agmatine concurrent with morphine for 5 days.