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Agmatine prevented down-regulation of the NR2B subunit, but not the NR1 subunit, of NMDARs in the hippocampus of chronic morphine-treated rats (n = 10; *P < 0.05 vs Con group, # P < 0.05 vs Mor group, one-way ANOVA followed by Bonferroni test). Con control, Mor morphine, Agm agmatine, Agm + Mor agmatine administered with morphine for 5 days.
