Table 1.
TFs associated with regeneration whose expression is also impacted by the GR (transcriptionally activated/repressed by GR)
| Transcription factor | Effect of GR on transcription |
|---|---|
| C/EBPα | + |
| C/EBPβ | + |
| COUP-TFII | + |
| c-Rel (NF-κB subunit) | + |
| HIF1A | + |
| IRF1 | + |
| NURR1 | + |
| p73 | + |
| PPAR-γ | + |
| SF1 | + |
| STAT3 | + |
| STAT5 | + |
| STAT5A | + |
| STAT5B | + |
| TBP | + |
| c-Jun/c-Fos | - |
| c-Rel (NF-κB subunit) | - |
| E2A | - |
| NF-AT2(NFATC1) | - |
| NF-κB | - |
| NF-κB1 (p50) | - |
| p53 | - |
| p73 | - |
| PIT1 | - |
| RelA (p65 NF-κB subunit) | - |
| SMAD3 | - |
| STAT6 | - |
| T-bet | - |
| ZNF307 | - |
Interactions were determined using MetaCore software and were identified in mouse, rat, and human.