Table 3.
Whole-brain analyses comparing BOLD responses (Internet-gaming > general Internet-surfing stimuli) between IGD and HC participants; (voxel-level P < 0.001, PFWE < 0.05)
| Hemisphere | Brain regions | BA | Cluster size | Cluster PFWE | Peak MNI (mm) | peak t value | ||
|---|---|---|---|---|---|---|---|---|
| X | Y | Z | ||||||
| IGD > HC | ||||||||
| R+L | Precuneus/middle occipital gyrus/fusiform gyrus/parahippocampal gyrus/posterior cingulate/brainstem/postcentral gyrus/inferior parietal gyrus/middle temporal gyrus/cerebellum/declive/superior temporal gyrus/midbrain/angular gyrus/associative visual cortex/inferior temporal gyrus/culmen/inferior temporal gyrus/lingual gyrus/hippocampus | 19, 20, 30, 37, 39 | 3821 | < 0.001 | 12 | −54 | 15 | 7.29 |
| R | IFG/DLPFC/middle frontal gyrus/superior frontal gyrus/precentral gyrus | 8, 9, 46 | 737 | < 0.001 | 51 | 12 | 24 | 6.83 |
| L | Precentral gyrus/IFG/DLPFC/middle frontal gyrus/superior frontal gyrus | 6, 8, 9, 46 | 1007 | < 0.001 | −51 | 6 | 42 | 6.78 |
| L+R | Cerebellum/uvula/declive/vermis | 684 | < 0.001 | −9 | −51 | −45 | 5.87 | |
| L+R | Cingulate gyrus/cingulum/posterior cingulate | 31 | 65 | 0.004 | −3 | −30 | 42 | 5.41 |
| L+R | Cingulum/anterior cingulate | 24 | 79 | 0.001 | −3 | 21 | 15 | 5.21 |
| L | Putamen/pallidum/caudate | 93 | 0.001 | −18 | 3 | 6 | 4.81 | |
| R | Putamen/caudate/pallidum | 147 | < 0.001 | 21 | 12 | 3 | 4.69 | |
| HC > IGD | ||||||||
| R | Operculum/insula | 13 | 50 | 0.016 | 45 | −18 | 15 | 5.08 |
| R | Precentral gyrus/postcentral gyrus/primary motor cortex/primary somatosensory cortex | 3, 4 | 161 | < 0.001 | 36 | −24 | 54 | 4.77 |
| R | Precentral/operculum/superior temporal gyrus/postcentral/premotor cortex | 6, 43 | 54 | 0.011 | 60 | −6 | 12 | 4.67 |
IGD = Internet gaming disorder; HC = healthy control; BA = Brodmann’s area; R= right; L= left; IFG = inferior frontal gyrus; DLPFC = dorsolateral prefrontal cortex.