Table 1.

Metabolic Control: 4–8 Months (Second Phase of the Study)

	Cb group			Co→Cb group
	4 months	8 months	*P	4 months	8 months	*P
HbA1c (%)	7.61 ± 0.58	7.73 ± 0.65	0.209	7.86 ± 0.87	8.01 ± 0.93	0.215
Change HbA1c (%)		+0.12 ± 0.56			+0.15 ± 0.6
No. of SMBG tests/day	4.75 ± 0.92	4.77 ± 1.07	0.886	5.16 ± 1.19	4.87 ± 1.2	0.219
Glycemia (mg/dL)
Total	159.8 ± 21.8	163.9 ± 21.0†	0.294	171.4 ± 28.8	176.5 ± 28.2†	0.218
Preprandial	160.4 ± 23.0	161.9 ± 22.9 ‡	0.682	169.1 ± 30.5	176.8 ± 32.7 ‡	0.077
Postprandial	166.8 ± 32.8	166.0 ± 24.1§	0.358	175.7 ± 39.3	181.7 ± 35.5§	0.301
No. of hypoglycemic episodes/2 weeks
Total	7.1 ± 4.0	7.8 ± 4.2**	0.426	5.9 ± 4.1	4.7 ± 3.5**	0.162
Preprandial	4.5 ± 3.3	4.7 ± 3.1	0.759	3.1 ± 2.7	3.7 ± 2.9	0.407
Postprandial	1.9 ± 1.5	2.2 ± 2.1††	0.468	2.3 ± 2.0	1.1 ± 1.2††	0.002
Nocturnal	0.7 ± 0.8	0.8 ± 1.4	0.571	0.5 ± 0.8	0.8 ± 1.0	0.313
<50 mg/dL	1.8 ± 1.9	1.6 ± 1.8‡‡	0.938	1.1 ± 1.3	1.0 ± 1.3‡‡	0.511
No. of hyperglycemic episodes >250 mg/dL/2 weeks
	8.23 ± 5.77	8.94 ± 5.54	0.536	11.77 ± 6.67	11.92 ± 7.01	0.914
SD total (mg/dL)	72.8 ± 14.21	78.35 ± 16.1	0.008	81.16 ± 23.61	78.91 ± 10.05	0.456
CV (%)	45.82 ± 8.81	47.69 ± 7.66	0.124	46.88 ± 7.83	44.60 ± 6.43	0.114
MAGE (mg/dL)	144.85 ± 55.16	140.78 ± 64.97	0.749	157.1 ± 51.81	139.75 ± 56.64	0.215
LBGI	2.75 ± 1.62	2.65 ± 1.26	0.738	1.95 ± 1.12	2.38 ± 3.67	0.555
HBGI	8.50 ± 4.23	10.38 ± 5.55	0.057	10.83 ± 5.33	10.63 ± 5.07	0.854
Insulin [IU/(kg·d)]
Basal	0.56 ± 0.24	0.53 ± 0.22	0.009	0.65 ± 0.28	0.64 ± 0.27	0.232
Prandial	0.32 ± 0.11	0.32 ± 0.12	0.834	0.33 ± 0.09	0.34 ± 0.09	0.784
Total	0.88 ± 0.29	0.85 ± 0.27	0.045	0.96 ± 0.31	0.95 ± 0.31	0.374

Mean ± SD.

^*P intragroups. Between groups at 8 months: ^†P 0.045; ^‡P 0.035; ^§P 0.032; ^**P 0.003; ^††P 0.006; and ^‡‡P 0.026.

Cb, BC group; Co, control group; CV, coefficient of variation; HBGI, high blood glucose index; LBGI, low blood glucose index; MAGE, mean amplitude of glycemic excursions; SD, standard deviation.