Table 1.
Stem Cell Populations Expressing Integrin α6 (CD49f)
| Cardiac stem cells | CD117(+)/Laminin1(+)/CD49f(+) | [77] |
| Cord blood stem cells | CD34(+)/CD90(+)/CD49f(+)/CD117(+) | [78] |
| Corneal epithelial stem cells | CD71(dim)/CD49f(bri) | [79] |
| Dental stem cells | Sca-1(+)/CD49f(bri)/CD44(+) | [80] |
| Embryonic stem cells | SSEA4(+)/SSEA3(+)/TRA-1-60(+)/TRA-1-81(+)/CD49f(+) | [29] |
| Epithelial odontogenic stem cells | CD49f(+) | [81] |
| Epithelial intestine stem cells | PHLDA1(+)/CD49f(+) | [82] |
| Esophageal epithelial stem cells | CD71(dim)CD49f(bri) | [83] |
| Gallbladder stem cells | EpCAM(+)/CD49f(hi) | [84] |
| Hair follicle stem cells | CD34(+)/CD49f(bri) | [85] |
| Hematopoietic stem cells | Thy1(+)/Rho(low)/CD49f(+) | [32] |
| Hepatic stem cells | Adult: CD49f(+)/CD29(+)/c-Kit(−)/Thy1.1(−) Fetal: c-Met(+)/CD49f(+/low)/c-kit(−)/CD45(−)/TER199(−) |
[86,87] |
| Keratinocyte stem cells | CD49f(bri)/10G7(dim); CD71(dim)CD49f(bri) | [10,88–90] |
| Lung epithelial stem cells | EpCAM(hi)/CD49f(+)/CD104(+)/CD24(low) | [91,92] |
| Mammary epithelial stem cells | CD24(+)/CD49f(hi); Sca(hi); CD45(−)/Ter119(−)/CD31(−)/Sca-1(low)/CD24(med)/CD49f(hi) | [33,93,94] |
| Mesenchymal stem cells | PODXL(hi)/CD49f(hi) | [44,95] |
| Merkel cell stem cells | Sca1(+)/CD200(+)/CD49f(+) | [96] |
| Myometrial stem cells | CD49f(+)/CD34(+) | [97] |
| Neural stem cells | CD49f(hi)/CD29(hi)/CD133(+); GFAPv/LeX(+)/CD49f(+))/CD29(+) | [47,48] |
| Oral epithelial stem cells | Ki-67(+)/CD29(+)/CD49f(hi)/keratin 13(low) | [98] |
| Primordial germ cells | SSEA1(+)/SSE3(+)/SSEA4(+)/EMA-1(+)/CD29(+), CD49f(+) | [99] |
| Prostate stem cells | CD45(−)/CD31(−)/Ter119(−)/Sca-1(+)/CD49f(+); Trop2(hi)/CD49f(hi)* | [100–102] |
| Salivary gland stem cells | CD49f(+)/Thy-1(+)/Laminin(+) | [103] |
| Sweat gland myoepithelial stem cells | CD29(hi)/CD49f(hi) | [104] |
| Spermatogonial stem cells | CD29(+)/CD49f(+) | [23] |
| Thymus stem cells | Sca1/(+)PDGFRa(+)/PDGFRb(+)/CD29(+)/CD44(+)/CD49f(+)/CD90(+) | [105] |
| Tracheal epithelial stem cells | CD49f(bri)/Sca1(+)/ALDH(+) | [106] |
| Breast cancer stem cells | CD44(+)/CD49f(+); CD44(+)/CD24(−)/CD49f(+)/NRP2(+) | [57,107] |
| Cervical cancer stem cells | CD34(+)/CD49f(+)/CD133(+); CK-17(+)/p63(+)/All(+)/CD49f(+)/ALDH(hi) | [50,51] |
| Esophageal adenocarcinoma stem cells | CD71(dim)/CD49f(bri) | [83] |
| Glioblastoma cancer stem cells | CD133(+)/CD49f(+) | [49] |
| Hepatocellular carcinoma stem cells | CD133(+)/CD49f(+) | [108] |
| Prostate cancer stem cells | CD49f(+)/CD44(+)/CD133(+); Lin(−)/Sca-1(+)/CD49f(+) | [109,110] |
| Ovarian endometrioma stem cells | Sal-like 4(+)/CD133(+)/Musashi-1(+)/CD49f(+) | [111] |
| Squamous cell carcinoma stem cells | CD34(+)/CD49f(hi)/CD29(hi) | [112] |
The bold text highlights the positive and common expression of CD49f among all the stem cell types listed in the table.