FIG. 8.

Oxidative stress underlies vascular remodeling, stiffness, and elastin alterations in hypertensive animal models. Wall/lumen (A,B) stress-strain curves (C, D) and fenestrae area and number (E, F) in MRAs from WKY, SHR, and SHR treated with apocynin (APO) or mito-TEMPO (mito-TP) (A, C) and (E) or from control, Ang II-infused, and Ang II-infused mice treated with apocynin or mitoTEMPO (B, D) and (F). Maximal projections of the IEL of MRAs from WKY, SHR, or SHR plus antioxidants (image size: 119 × 119 μm) (E) and control, Ang II, and Ang II plus antioxidant-treated mice (image size: 59.5 × 59.5 μm) (F). Data are represented as mean ± SEM (n = 6–15; *p < 0.05, **p < 0.01, ***p < 0.001 vs. WKY or control animals; +p < 0.05, ++p < 0.01, +++p < 0.001 vs. untreated WKY or Ang II-infused animals). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars