TABLE 2.

Logistic regression coefficients and P values for the optimal classification model incorporating the covariates deltadiff, EC₅₀ VEH, EC₅₀ TNF, delta VEH, and C_max

Covariate	β	χ2	P Value
Intercept	−1.924	7.091	0.008
Deltadiff	0.108	2.471	0.116
EC50 VEH	−0.066	6.215	0.013
EC50 TNF	0.050	4.480	0.034
DeltaVEH	0.081	11.038	0.001
Cmax	0.0031	0.129	0.720

The coefficients (β values) were computed using Firth’s approach as described in the Materials and Methods (Firth, 1993). A P value < 0.05 indicates that the covariate contributes significantly to the prediction of outcome (IDILI liability).