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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Expert Opin Drug Discov. 2017 Mar 14;12(5):475–487. doi: 10.1080/17460441.2017.1303478

Figure 3. Diversification of polyketide scaffolds by genetic engineering of PKS clusters.

Figure 3

Possible modifications to polyketide structures are colored according to the responsible PKS domains or stand-alone (post-PKS) enzymes. The changes are not mutually exclusive and can be made in combination. Reproduced and adapted from [121] with permissions from The Royal Society of Chemistry.