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The SUMO E3 ligase enhances NR4A1 SUMOylation, and the deSUMOylation enzyme decreases NR4A1 SUMOylation. (a and b) HEK293T cells stably expressing Myc-Ub were transfected with Flag-NR4A1, HA-SUMO3, and PIAS3 (a) or with SENP WT/CS (b) as indicated. Cells were treated with the proteasome inhibitor MG132 for (5 μM for 5 h) and then collected for immunoprecipitation (IP) and immunoblot (IB) analysis
