FIG. 4.

Outcome of CD8β depletion in two additional SIV-infected macaques manifesting control of chronic phase viremia. (A) The Mamu-B*08⁺ rhesus macaques r09089 and r09037 were rectally infected with SIVmac239 as part of a recent experiment conducted by our laboratory and controlled chronic phase viremia.³² Similar to the procedure described in Figure 3, these animals received a single infusion of 50 mg/kg of the CD8β255R1 mAb. At the time of the CD8β depletion, r09089 was at week 103 PI and r09037 was at week 109 PI. (B–E) Absolute lymphocyte counts in blood following the CD8β and CD8α depletions. (B) CD8αβ⁺ T cells (live CD3⁺CD8αα⁻CD8αβ⁺ lymphocytes). (C) NK cells (live CD3⁻CD8αα⁺CD16⁺ lymphocytes). (D) CD8αα⁺ T cells (live CD3⁺CD8αα⁺CD8αβ⁻lymphocytes). (E) CD4⁺ T cells (considered as live CD3⁺CD8αα⁻CD8αβ⁻lymphocytes). (F) Log-transformed VLs after the CD8β depletion.