Table 2.
Device Output and Delivery Comparison
| Device | Emitted rate (μL/min) | Expected lung deposition rate (μL/min)a | NaCl deposition rate (mg/min)b | NaCl deposited per day (mg) |
|---|---|---|---|---|
| tPAD | 24 (9) | 9.4 | 0.67 | 384c |
| PARI LC Star | 121 (13) | 43.6 | 3.1 | 151d |
Mean values (SD) for output and anticipated lung delivery with tPAD and LC Star devices.
a
Calculation utilizes the deposition fraction for each device that was measured in this study (39% of emitted dose from tPAD and 36% of emitted dose from LC Star).
b
Calculation made for 7% NaCl solution.
c
Presumes tPAD is used for 8 hours (e.g., overnight).
d
For PARI LC Star, presume that 3 mL of the 4 mL loaded dose is nebulized (i.e., 1.0 mL dead volume), that the device is used twice daily, and that 36% of this emitted dose deposits in the lung.