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| Midazolam | Propofol | Ketamine | Dexmedetomidine | |
|---|---|---|---|---|
| Chemical structrure |  |
 |
 |
 |
| Aqueous solubility | High (at pH < 4) | Low | Low | Low |
| Low (at pH > 4) | ||||
| Distribution half-life | 6-15 min | 2-8 min | 10-15 min | 6 min |
| Elimination half-life | 1.7-3.5 h | 4-7 h | 2-3 h | 2-3 h |
