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ARF-induced p53 activation requires BRCA1. Western blot analysis of NARF2 whole-cell lysates showing the induction of ARF, p53, phospho-serine 15 p53 and p21. Cells were doubly transfected with either ATR (oligos A and B combined), BRCA1 or control siRNAs as indicated. BRCA1 siRNA validation is shown in Supplementary Figure 1I.
