Table 2.
Oxidative and inflammatory status in ascites due to ovarian cancer. The significant difference between study groups treated with platinum and the concentrations of LPO and 8-IP in ascites fluid is noteworthy.
| Platinum-sensitive | Platinum-resistant | Platinum-refractory | p ∗ (K-W) | |
|---|---|---|---|---|
| Antioxidant | ||||
| TAC mM trolox | 871.00 ± 137.90 | 899.90 ± 152.70 | 1008.80 ± 138.90 | 0.60 |
| Oxidants | ||||
| LPO μM | 14.90 ± 9.30 | 27.10 ± 23.90 | 3.40 ± 1.50 | 0.05 ∗ |
| 8-IP pg/mL | 86.62 ± 26.70 | 36.70 ± 23.80 | 17.10 ± 1.50 | 0.03 ∗ |
| Proinflammatory cytokines | ||||
| IL-6 pg/mL | 1582.60 ± 346.10 | 969.60 ± 76.30 | 1382.30 ± 257.60 | 0.31 |
| TNF-α pg/mL | 146.10 ± 62.80 | 102.00 ± 27.50 | 75.10 ± 17.90 | 0.52 |
TAC: total antioxidant capacity; LPO: lipoperoxides; 8-IP: isoprostanes; IL-6: interleukin-6; TNF-α: tumor necrosis factor alpha; K-W: Kruskall-Walis test. ∗Comparison between treatment response groups.