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Amine Metabolism with Antifolates. A) Biotransformation of PAS, sulfanilamide, sulfamethoxazole and dapsone in M. tuberculosis. B) Metabolomics analysis showed concentration–dependent formation of PAS–derived Ia & IIa and N–methyl PAS Ib & IIb after exposure of M. tuberculosis to PAS for 18 h [53].
