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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Curr Opin Struct Biol. 2017 Jul 18;47:77–87. doi: 10.1016/j.sbi.2017.06.010

Figure 1.

Figure 1

Tetrahymena and human telomerase holoenzymes. (a) Front (left) and back (right) views of Tetrahymena telomerase cryo-EM map at ~9Å resolution (RNP core, blue; CST, tan; TEB, straw; and p50, red) and pseudoatomic models of the RNP core and TEB and CST trimerization domains of 3 OB-folds [13]. Tetrahymena telomerase protein domains for which structures have been determined are rendered as ribbons and with bases, respectively; homology models are rendered with ribbons and cylinders. TER single-stranded regions are shown as ribbons except the template which includes bases; folded domains are shown with bases. (b, d) Schematics illustrating (b) Tetrahymena and (d) human TER secondary structure and domains, TER interacting proteins, and proteins that interact with the RNP core. Proteins or complexes with generally homologous functions between organisms are colored the same, except H/ACA scaRNP proteins which are distinguished from each other. (c, e) Schematics of (c) Tetrahymena and (e) human interactions at telomere 3′ ends. Dashed green line indicates extension of the 3′ end by telomerase. In (e), lines with arrowheads indicate transient interactions and lines with bars indicate inhibitory interactions. Panels b-e are modified from [8].