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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Curr Opin Struct Biol. 2017 Jul 18;47:77–87. doi: 10.1016/j.sbi.2017.06.010

Figure 2.

Figure 2

Structure of TERT and interaction with TER. (a) Structure of flour beetle TERT with bound inhibitor BIBR1532 (PDB ID: 5CQG). The model is shown in the classical polymerase hand view (pale green) with RT palm (purple), fingers (orange), IFD (gold), CTE thumb (light blue), and TRBD (blue). Active site on RT is space-filled red. (b) Hand view of structure of Tetrahymena TERT with bound TER. Note that this view is rotated 180° at the Y-axis from the cryo-EM model back view in Figure 1a. (c) Tetrahymena TRBD-TBE complex (PDB ID: 5C9H), TBE is red, T motif is cyan, CP is gold, and CP2 is purple. (d) Human CTE (thumb) (PDB ID: 5UGW). (e) Model of human TERT bound to human TER t/PK based on the model of the human t/PK and the positions of homologous domains of Tetrahymena TR in the cryo-EM map. The dash line indicates the proposed location of P6.1. Subdomains of TERT and TR are colored as in Figure 1, except human TER J2a/b is colored as green.