Table 1.
Phosphoprotein Activation Patterns in Tumor Signaling Subgroups of Brain Metastases from Lung Cancera
| ERBB signaling | apoptosis/DNA damage response | AKT-mTOR signaling | AMPK signaling | MAPK signaling | IGFR signaling | VEGFR signaling | |
|---|---|---|---|---|---|---|---|
| Group A | EGFR Y1068↑ | p53↑ | mTOR S2481↔ | IGF1R-IR | |||
| EGFR Y1045↑ | BCL-2 T56↑ | p70S6K S371↑ | Y1131–Y1146↑ | ||||
| EGFR Y992↑ | BCL-2 S70↑ | IGF1R-IR | |||||
| Total ERBB4↑ | Y1135/6-Y1150/1↑ | ||||||
| ACK1 Y857/858↑ | IRS1 S612↑ | ||||||
| Group B | Total EGFR↑ | Cleaved Caspase 3 D175↑ | mTOR S2481↔ | ELK1 S383↑ | VEGFR2 Y951↑ | ||
| EGFR | Cleaved Caspase 9 D315↑ | mTOR S2448↑ | |||||
| S1046/1047↑ | Cleaved PARP D214↑ p53↑ | ||||||
| Group C | Total ERBB2↑ | Cleaved Caspase 3 D175↑ | mTOR S2481↔ | AMPKα S485↑ | MEK1/2 S217/221↑ | VEGFR2 Y951↑ | |
| EGFR Y1148↔ | Cleaved Caspase 9 D330↑ | mTOR S2448↑ | LKB1 S334↑ | ERK1/2 T202/Y204↑ | VEGFR2 Y996↑ | ||
| EGFR Y1173↔ | Cleaved PARP D214↑ | p38 MAPK T180/Y182↑ | VEGFR2 | ||||
| BAD S136↑ | CREB S133↑ | Y1175↑ | |||||
| BAD S155↑ | |||||||
| Group D | ERBB2 Y1248↑ | Cleaved Caspase 9 D315↑ | mTOR S2481↔ | AMPKα S485↑ | A-RAF S299↑ | VEGFR2 Y996↑ | |
| Total ERBB2↑ | mTOR S2448↔ | AMPKβ S108↑ | MEK1/2 S217/221↑ | ||||
| EGFR Y1148↑ | LKB1 S334↑ | ERK1/2 T202/Y204↑ | |||||
| EGFR Y1173↑ | p38 MAPK T180/Y182↑ | ||||||
| ELK1 S383↑ | |||||||
| CREB S133↔ | |||||||
| Group E | EGFR Y1068↑ | Cleaved Caspase 3 D175↑ | AKT T308↑ | AMPKα S485↑ | A-RAF S299↑ | IGF1R-IR | |
| EGFR Y1045↑ | Cleaved Caspase 9 D315↑ | AKT S473↑ | AMPKβ S108↑ | B-RAF S445↑ | Y1131–Y1146↑ | ||
| EGFR Y992↑ | Cleaved Caspase 9 D330↑ | mTOR S2481↑ | LKB1 S334↑ | MEK1/2 S217/221↑ | IGF1R-IR | ||
| EGFR Y1148↑ | p53↑ | mTOR S2448↑ | Y1135/6-Y1150/1↑ | ||||
| EGFR Y1173↑ | CHK2 S33/35↑ | PTEN S380↑ | IRS1 S612↑ | ||||
| ERBB3 Y1197↑ | BCL-2 T56↑ | p70S6K S371↑ | |||||
| ERBB3 Y1289↑ | BCL-2 S70↑ | p70S6K T389↑ | |||||
| Total ERBB4↑ | BAD S112↑ | ||||||
| Total ERBB3↑ | BAD S136↑ | ||||||
| Total ERBB2↑ | BAD S155↑ |
a
↑ = high relative expression in a subgroup; ↔ = intermediate relative expression in a subgroup.