Table 1.
Partial List of Up-regulated Metabolic Proteins in PANC-1
| proteins | functional annotationa | accession number | average spectra count | |
|---|---|---|---|---|
|
| ||||
| normal duct | PANC-1 | |||
| pyruvate kinase, muscle isoform M1 | glycolysis | 33286420 | 39.0 | 100.0 |
| pyruvate kinase, muscle isoform M2 | glycolysis | 33286418 | 20.3 | 76.7 |
| enolase 2 | glycolysis | 5803011 | 61.0 | 271.0 |
| L-lactate dehydrogenase B | pyruvate fermentation | 4557032 | 2.7 | 45.7 |
| glucose-6-phosphate dehydrogenase isoform b | pentose phosphate pathway | 108773793 | 1.3 | 41.0 |
| ATP citrate lyase isoform 1 | fatty acid synthesis | 38569421 | 3.7 | 24.0 |
| fatty acid synthase | fatty acid synthesis | 41872631 | 5.0 | 125.0 |
| acyl-CoA thioesterase 7 isoform hBACHa | fatty acid metabolism | 75709208 | 0.0 | 5.7 |
| CTP synthase | pyrimidine biosynthesis | 148491070 | 0.0 | 36.0 |
| uridine monophosphate synthase | pyrimidine biosynthesis | 4507835 | 0.3 | 4.3 |
| phosphoribosylglycinamide formyltransferase | purine synthesis | 209869993 | 2.0 | 9.0 |
| adenylosuccinate lyase isoform a | purine synthesis | 4557269 | 0.0 | 4.3 |
| 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | purine synthesis | 20127454 | 5.0 | 28.3 |
| inosine monophosphate dehydrogenase 2 | purine synthesis | 66933016 | 2.0 | 12.3 |
| phosphoribosylformylglycinamidine synthase | purine metabolism | 31657129 | 0.0 | 6.7 |
| guanine monophosphate synthetase | purine metabolism | 4504035 | 3.3 | 15.7 |
| hypoxanthine phosphoribosyltransferase 1 | purine salvage | 4504483 | 0.0 | 16.0 |
| acetyl-Coenzyme A acetyltransferase 2 | mevalonate pathway | 148539872 | 0.0 | 8.3 |
| 24-dehydrocholesterol reductase precursor | cholesterol synthesis | 13375618 | 0.0 | 4.0 |
| ornithine aminotransferase precursor | proline synthesis | 4557809 | 0.0 | 14.0 |
| phosphoserine aminotransferase 1 isoform 2 | serine synthesis | 10863955 | 0.0 | 6.7 |
| methylenetetrahydrofolate dehydrogenase 1 | one carbon metabolism | 222136639 | 1.0 | 14.7 |
| methylenetetrahydrofolate dehydrogenase 2 | one carbon metabolism | 94721354 | 0.0 | 5.7 |
| carnitine palmitoyltransferase 1A liver isoform 1 | fatty acid metabolism | 73623030 | 0.0 | 4.0 |
| UDP-glucose dehydrogenase | nucleotide-sugar synthesis | 4507813 | 12.0 | 37.0 |
| UDP-N-acetylglucosamine pyrophosphorylase 1 | nucleotide-sugar synthesis | 156627575 | 0.3 | 12.3 |
| UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase isoform 2 | N-acetylneuraminic acid biosynthesis | 4885285 | 0.0 | 3.0 |
a
Functional annotation is based on Protein Knowledgebase at http://www.uniprot.org.