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. Author manuscript; available in PMC: 2017 Aug 21.
Published in final edited form as: Clin Pharmacokinet. 2016 Jan;55(1):107–119. doi: 10.1007/s40262-015-0301-3

Table 2.

Subject demographics for continuous covariates tested in the model-building dataset

Characteristic N Mean SD CV Median Range
Current body weighta (kg) 35   2.30   1.22   0.530   2.80 0.46–4.20
Current body lengtha (cm) 34 43.4   9.15   0.211 47.5 25.0–56.0
BMI (kg/m2) 34 11.1   2.91   0.263 12.0 6.04–16.7
Gestational age (weeks) 35 33.6   6.57   0.196 37 23–41
Postnatal agea (days) 35   7.49   5.73   0.766   6 1–26
Postmenstrual agea (weeks) 35 34.6   6.28   0.181 37.6 23.1–41.6
Total bilirubin (mg/dL) 22   6.65   4.88   0.734   4.8 0.9–17.5
Serum creatinineb (mg/dL) 30   0.707   0.242   0.342   0.7 0.3–1.1
Estimated GFRc (mL/min/1.73 m2) 29 30.1 16.6   0.551 24.1 12.6–70.9

BMI body mass index, CV coefficient of variation, GFR glomerular filtration rate, SD standard deviation

a

On the day of the first paracetamol dose

b

Serum creatinine concentrations obtained at ≤3 days postnatal age were considered to reflect maternal renal function and were excluded from the analysis

c

Estimated GFR was calculated using the updated Schwartz formula (Eq. 2) [26]