Table 4.
Darbe PK following the first and second study doses
| Low-dose Darbe2 μg/kg (median, IQR) |
High-dose Darbe Darbe 10 μg/kg (median, IQR) |
P value | |
|---|---|---|---|
| Darbe first dose | |||
| AUCinf (h*mU/ml) |
26,555 (20,049–35,029) |
180,886 (146,568–199,680) |
0.006 |
| t1/2(h) | 24 (20–28) |
32 (23–58) |
0.145 |
| MRT (h) |
34 (29–40) |
46 (32–83) |
0.145 |
| CL (l/h) |
0.05 (0.03–0.06) |
0.04 (0.03–0.05) |
0.665 |
| Cmax(mU/ml) | 1,220 (1,013–6,468) |
6,309 (3,670–6,468) |
0.027 |
| Darbe second dose | |||
| AUCinf (h*mU/ml) |
10,790 (7,043–13,493) |
56,233 (54,915–71,260) |
0.003 |
| t1/2(h) | 26 (23–33) |
35 (26.5–41) |
0.414 |
| MRT (h) |
37 (33–48) |
51 (38–59) |
0.414 |
AUCinf, area under the curve, extrapolated to infinity; Cmax, maximal concentration; MRT, mean residence time; t1/2, terminal half-life.