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. 2017 Mar 29;42(9):1871–1883. doi: 10.1038/npp.2017.41

Figure 4.

Figure 4

Effects of R-MOD and JJC8-016 on cocaine-primed reinstatement of cocaine-seeking behavior. (a, b) Active lever responses during the last session of cocaine self-administration, last session of extinction, and reinstatement testing illustrating that pretreatment with R-MOD (a) or JJC8-016 (b) dose-dependently inhibited cocaine-triggered reinstatement of drug-seeking behavior. A threefold higher dose (100 mg/kg) of R-MOD than JJC8-016 (30 mg/kg) is required to produce this inhibitory effect. (c, d) Active lever responses during the last session of cocaine self-administration, extinction, and reinstatement testing illustrating that R-MOD, at 100 mg/kg, induced reinstatement of cocaine-seeking behavior, whereas JJC8-016 did not at each drug dose (10 and 30 mg/kg). *P<0.05 and **p<0.001 compared with the vehicle control.