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Knockdown of IGF2BP1 inhibits expression of MAPK signaling, inducing the activation of p21/caspase-3 dependent mitochondrial apoptosis process in HepG2 cells. (A) RT2-PCR validation showed downregulation of HCG11 after IGF2BP1 inhibition. (B) Western blotting validation showed downregulation of IGF2BP1, p-p38, p-ERK, p-JNK and upregulation of p21 and cleaved caspase-3 after IGF2BP1 inhibition in HepG2 cells. **P<0.01 vs. HepG2+NC group.
