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. 2017 Jul 5;51(3):791–800. doi: 10.3892/ijo.2017.4066

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Knockdown of HCG11 inhibits expression of IGF2BP1 and MAPK signaling, which induced the activation of p21/caspase-3 dependent mitochondrial apoptosis process in HepG2 cells. (A) RT2-PCR validation showed downregulation of HCG11 after HCG11 inhibition. (B) RT2-PCR validation showed downregulation of IGF2BP1 after HCG11 inhibition in HepG2 cells. (C) Western blotting validation showed downregulation of IGF2BP1, p-p38, p-ERK, p-JNK and upregulation of p21 and cleaved caspase-3 after HCG11 inhibition in HepG2 cells. ^**P<0.01 vs. HepG2+NC group. ^***P<0.001 vs. HepG2+NC group.