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. Author manuscript; available in PMC: 2018 Jul 26.
Published in final edited form as: Cell Syst. 2017 Jul 26;5(1):72–81.e4. doi: 10.1016/j.cels.2017.06.013

Figure 4. Incoherent Inputs Are Enriched in Biological and Synthetic Oscillators.

Figure 4

(A) Examples of biological oscillators with incoherent inputs. Networks are shown for mammalian circadian clock (Bell-Pedersen et al., 2005), cardiomyocyte calcium spike (Liu and Priori, 2008; Periasamy et al., 2008), zebrafish segmentation clock (Mara and Holley, 2007), nuclear factor κB oscillation (Nelson et al., 2004; Zambrano et al., 2016), and p38 oscillation (Tomida et al., 2015). The nodes with incoherent inputs are labeled in green.

The signal inputs are labeled in red. The dotted line represents intercellular interaction.

(B) Example of synthetic oscillators with incoherent inputs (Atkinson et al., 2003; Butzin et al., 2016; Chen et al., 2015; Fung et al., 2005; Hussain et al., 2014; Stricker et al., 2008; Tigges et al., 2009, 2010; Toettcher et al., 2010).