Table 3. MSCs are present in primary prostate cancer tissue independent of inflammation status.
| Sample | Age (yrs) |
% MSCs | Gleason Score |
Inflammation | ||
|---|---|---|---|---|---|---|
| Cancer | Benign | Atrophy | ||||
| PCa-1 | 69 | 1.10 | 3+4 | Mild | None | Moderate, Non-Focal |
| PCa-2 | 70 | 1.06 | 4+5 | None | Mild | - |
| PCa-3 | 66 | 1.03 | 3+4 | - | Moderate, Non-Focal | - |
| PCa-4 | 55 | 0.98 | 3+4 | None | Mild | - |
| PCa-5 | 60 | 0.45 | 3+3 | - | Mild | Mild |
| PCa-6 | 70 | 0.38 | 3+3 | Mild | Mild | - |
| PCa-7 | 65 | 0.38 | 4+5 | N/A | N/A | N/A |
| PCa-8 | 63 | 0.28 | 4+5 | None | Mild | None |
| PCa-9 | 68 | 0.28 | 3+4 | None | Mild | Mild |
| PCa-10 | 70 | 0.25 | 3+4 | Mild | Mild | None |
| PCa-11 | 59 | 0.23 | 4+5 | Mild | Mild | Mild |
| PCa-12 | 51 | 0.22 | 3+3 | None | Mild | - |
| PCa-13 | 58 | 0.22 | 3+3 | - | Acute, Mild | None |
| PCa-14 | 70 | 0.21 | 5+4 | - | None | None |
| PCa-15 | 55 | 0.19 | 4+3 | Mild | Moderate | Mild |
| PCa-16 | 65 | 0.14 | 4+3 | None | None | None |
| PCa-17 | 61 | 0.08 | 3+4 | Mild | None | None |
| PCa-18 | 70 | 0.08 | 4+3 | Mild | Chronic, Mild, Non-Focal | None |
| - | Acute, Moderate | - | ||||
| PCa-19 | 57 | 0.07 | 4+5 | None | None | None |
| PCa-20 | 54 | 0.06 | 4+3 | - | None | - |
| PCa-21 | 59 | 0.06 | 4+5 | Mild, Non-Focal | Mild | Mild |
| PCa-22 | 64 | 0.06 | 4+3 | None | None | None |
| PCa-23 | 59 | 0.02 | 4+5 | - | None | Mild |
| PCa-24 | 57 | 0.01 | 3+4 | Mild | None | - |
| PCa-25 | 73 | 0.01 | 3+4 | - | None | Mild |
| PCa-26 | 70 | <0.01 | 3+4 | None | None | None |
| PCa-27 | 63 | <0.01 | 4+3 | Moderate, Non-Focal | Mild, Non-Focal | None |
| PCa-28 | 49 | <0.01 | 4+4 | None | None | - |
| PCa-29 | 53 | <0.01 | 4+3 | None | Mild | - |
| PCa-30 | 62 | <0.01 | 4+5 | None | Mild | - |
| PCa-31 | 68 | <0.01 | 3+4 | - | Mild | Mild |
Percent of cells defined as MSCs in radical prostatectomy tissue from men with prostate cancer by flow cytometry (mean: 0.3%; median: 0.1%). No association between the number of MSCs detected and the level of inflammation present in the tissue is observed. Benign, atrophic, and malignant areas were scored where appropriate for the type (chronic or acute) and intensity (none, mild, moderate, or severe) of inflammation present and whether it was focal or non-focal. Unless otherwise noted, all inflammation observed was chronic and focal. Notes: Tissue was unavailable for IHC analysis in PCa-7. PCa-18 had areas of chronic and acute inflammation. ‘-’ denotes not present in this sample