Table 3. Multivariate analysis of the impact of CD3i – and PD-L1 status on overall survival.

		HR (OS)	lower CI (95%)	upper CI (95%)	p-value
Gender	male	1.000			0.026
	female	0.518	0.290	0.925
Age	per year	1.022	0.994	1.051	0.121
pT	1	1.000			<0.001
	2	3.345	1.918	5.834
	3	1.693	0.875	3.276
	4	2.068	0.223	19.211
pN	0	1.000			0.038
	1	1.441	0.879	2.361
	2	0.554	0.149	2.057
	3	6.048	1.288	28.387
CD3i	high	1.000			0.011
	low	1.925	1.159	3.200
		HR (OS)	lower CI (95%)	upper CI (95%)	p-value
Gender	male	1.000			0.044
	female	0.551	0.308	0.985
Age	per year	1.026	0.997	1.056	0.077
pT	1	1.000			0.001
	2	3.025	1.736	5.272
	3	1.723	0.893	3.325
	4	2.962	0.343	25.556
pN	0	1.000			0.040
	1	1.471	0.892	2.426
	2	0.602	0.168	2.163
	3		5.952	1.269	27.904
CD3i	diffuse	1.000			0.010
Distribution	focal	1.941	1.173	3.210
		HR (OS)	lower CI (95%)	upper CI (95%)	p-value
Gender	male	1.000			0.088
	female	0.597	0.329	1.080
Age	per year	1.022	0.995	1.049	0.112
pT	1	1.000			<0.001
	2	3.415	1.978	5.895
	3	1.956	1.013	3.777
	4	5.081	0.529	48.760
pN	0	1.000			0.048
	1	1.248	0.773	2.014
	2	0.388	0.105	1.432
	3	5.210	1.110	24.457
PD-L1 TCs	high	1.000			0.026
	low	1.801	1.074	3.021