Figure 1. Higher MCL-1 protein expression in melanomas compared with Melanocytes.

Immunoblot of MCL-1 expression in lysates from melanoma cells and melanocytes cultured in sphere condition. Melanomas include common cell lines and short term cultures of melanoma samples relapsed from current treatments, with BRAF-mutated (HT144, 451Lu, and MB2309), NRAS-mutated (SKMEL-30, WM852c and Hs852T), NF-null (Hs852T), or wild-type for common mutations in BRAF, NRAS, or NF1 (MB2141).