Table 2. Meta-analysis results of the association between rs895819 and cancer risk.
| Variables | Na | G vs. A | GG vs. AA | AG vs. AA | GG+AG vs. AA | GG vs.AG+AA | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | I2 (%) | OR (95% CI) | I2 (%) | OR (95% CI) | I2(%) | OR (95% CI) | I2 (%) | OR (95% CI) | I2(%) | ||
| Overall | 28 | 1.03 (0.97,1.10)b | 56.4 | 1.12 (0.97,1.29)b | 52.2 | 0.99 (0.91,1.06)b | 42.6 | 1.01 (0.94,1.09)b | 49.7 | 1.11 (0.97,1.26)b | 49.6 |
| Ethnicity | |||||||||||
| Asians | 22 | 1.05 (0.97,1.13)b | 55.9 | 1.13 (0.95,1.34)b | 54.2 | 1.02 (0.93,1.11)b | 36.6 | 1.04 (0.95,1.13)b | 44.9 | 1.10 (0.93,1.30)b | 54.9 |
| Caucasians | 6 | 0.94 (0.88,1.01) | 48.7 | 0.98 (0.83,1.15) | 36.8 | 0.87 (0.79,0.96) | 43.0 | 0.89 (0.81,0.98) | 49.0 | 1.05 (0.90,1.22) | 23.1 |
| Cancer type | |||||||||||
| BC | 9 | 0.93 (0.87,0.99) | 0.0 | 0.90 (0.78,1.04) | 0.0 | 0.97 (0.84,1.11)b | 50.3 | 0.91 (0.83,0.99) | 33.7 | 0.92 (0.80,1.05) | 0.0 |
| CRC | 5 | 1.19 (1.08,1.32) | 9.9 | 1.58 (1.28,1.96) | 0.0 | 0.98 (0.85,1.14) | 29.3 | 1.11 (0.97,1.27) | 23.0 | 1.58 (1.29,1.93) | 0.0 |
| LC | 2 | 0.95 (0.82,1.11) | 0.0 | 1.02 (0.69,1.51) | 0.0 | 0.90 (0.74,1.09) | 0.0 | 0.91 (0.76,1.10) | 0.0 | 1.07 (0.73,1.57) | 0.0 |
| GC | 5 | 1.06 (0.87,1.29)b | 75.7 | 1.08 (0.68,1.70)b | 74.7 | 1.06 (0.86,1.31)b | 60.8 | 1.08 (0.85,1.36)b | 70.9 | 1.05 (0.71,1.56)b | 68.6 |
| ESCC | 2 | 1.00 (0.89,1.12) | 25.4 | 0.95 (0.72,1.26) | 54.1 | 1.03 (0.89,1.19) | 0.0 | 1.02 (0.88,1.17) | 0.0 | 0.94 (0.72,1.24) | 52.4 |
| Others | 5 | 1.09 (0.84,1.41)b | 74.3 | 1.35 (0.73,2.49)b | 69.0 | 0.99 (0.75,1.31)b | 59.5 | 1.05 (0.77,1.43)b | 69.4 | 1.35 (0.80,2.28)b | 60.5 |
| Source of controls | |||||||||||
| PB | 10 | 1.04 (0.94,1.15)b | 55.9 | 1.05 (0.91,1.21) | 22.2 | 1.06 (0.90,1.24)b | 63.7 | 1.07 (0.92,1.24)b | 63.8 | 1.03 (0.90,1.18) | 15.2 |
| HB | 18 | 1.03 (0.94,1.11)b | 59.0 | 1.12 (0.91,1.37)b | 61.7 | 0.94 (0.88,1.01) | 21.4 | 0.99 (0.90,1.08)b | 40.5 | 1.14 (0.94,1.37)b | 58.9 |
a: number of studies; b: calculating based on random-effects model; BC: breast cancer; CRC: colorectal cancer; LC: lung cancer; GC: gastric cancer; ESCC: esophageal squamous cell carcinoma.