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. 2017 Apr 3;8(29):47052–47063. doi: 10.18632/oncotarget.16789

Figure 6. Effects of TROP2 on EMT and PI3K/AKT pathway in GBC-SD and SGC-996 cells in vitro.

Figure 6

(A) Knockdown of TROP2 expression inhibited vimentin and increased E-cadherin protein expression. (B) Overexpression of TROP2 increased vimentin and decreased E-cadherin protein expression. (C) Knockdown of TROP2 increased total PTEN, p-PTEN and PDK-1 protein expression, but inhibited p-AKT expression. (D) Overexpression of TROP2 decreased total PTEN, p-PTEN and PDK-1 protein expression, but increased p-AKT expression.