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. 2017 May 2;8(29):47136–47153. doi: 10.18632/oncotarget.17559

Figure 9.

Figure 9

Fate of DOX and in vivo toxicity evaluation after i.v. administration of liposomal formulations equal to toxic dose (DOX = 15 mg/kg), via tail vein of Kunming mice (n = 3) (A) In vivo DOX signaling in anesthetized Kunming mice (B) GSH-Px activity in whole blood and plasma after 24 h (C) GSH-Px activity in heart, liver and kidney; (D) Production of arachidonic acid metabolite (20-HETE) after 24 h (E) Histopathological evaluation of body organs (HT: heart; LR: liver; KD: kidney; SP: spleen; LG: lung) (H and E staining; 200 μm region under 10× magnification of fluorescence microscope) after 24 h. The results were compared with ODL formulation and represented as: P < 0.05 (*), P < 0.01 (**), P <0.001 (***), P <0.0001 (****).