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. 2017 May 3;8(29):47216–47229. doi: 10.18632/oncotarget.17590

Figure 6. Exogenous SULF1 expression promotes UC cells proliferation in vitro.

Figure 6

Exogenous expression of wild-type and mutant (delta CC) SULF1 has been performed in SULF1-low-expressing BFTC909 cell line. The efficiency is confirmed by both quantitative RT-PCR (A) and western blotting assays (B). The significant increased phosphorylated Akt can be detected in that with wild-type SULF1, while not in that with delta CC mutation, suggesting the activation of Akt pathway is associated with enzymatic function of SULF1. Exogenous expression of wild-type SULF1 significantly promotes cell proliferation (C). That with delta CC mutated SULF1 revealed a proliferation rate between control cells and that with wild-type SULF1, indicating the oncogenic role of SULF1 may be partly relay on its enzymatic function.