Table 3. Combined and interactive effects of microRNA–binding site polymorphisms in IL13 and dietary factors on the risk of colorectal cancer.
| SNPs | Dietary factors | Cases (No.) | Controls (No.) | Adjusted ORdg (95% CI) | P– value | Adjusted ORi (95% CI) | P– value* |
|---|---|---|---|---|---|---|---|
| rs847 | Allium vegetables# (times/week) | 0.92 (0.84–1.01) | 0.08 | ||||
| GG | < 1 | 83 | 69 | 1 | |||
| GG | 1–3 | 59 | 68 | 0.85 (0.52–1.39) | 0.53 | ||
| GG | 4–6 | 34 | 59 | 0.51 (0.30–0.88) | 0.02 | ||
| GG | > 7 | 71 | 79 | 0.81 (0.51–1.29) | 0.37 | ||
| AG+AA | < 1 | 70 | 64 | 0.92 (0.57–1.49) | 0.74 | ||
| AG+AA | 1–3 | 61 | 75 | 0.68 (0.42–1.10) | 0.11 | ||
| AG+AA | 4–6 | 50 | 68 | 0.65 (0.39–1.08) | 0.09 | ||
| AG+AA | > 7 | 80 | 88 | 0.83 (0.53–1.32) | 0.44 | ||
| rs847 | Overnight meal$ (times/week) | 1.25 (1.08–1.43) | 0.002 | ||||
| GG | < 1 | 47 | 64 | 1 | |||
| GG | 1–3 | 96 | 121 | 1.11 (0.69–1.79) | 0.68 | ||
| GG | > 3 | 104 | 92 | 1.66 (1.02–2.70) | 0.04 | ||
| AG+AA | < 1 | 54 | 63 | 1.14 (0.67–1.97) | 0.63 | ||
| AG+AA | 1–3 | 96 | 142 | 0.90 (0.56–1.45) | 0.67 | ||
| AG+AA | > 3 | 111 | 88 | 1.84 (1.13–3.01) | 0.01 | ||
| rs848 | Allium vegetables (times/week) | 0.92 (0.86–0.99) | 0.03 | ||||
| GG | < 1 | 84 | 69 | 1 | |||
| GG | 1–3 | 57 | 70 | 0.79 (0.48–1.29) | 0.34 | ||
| GG | 4–6 | 35 | 57 | 0.53 (0.31–0.91) | 0.02 | ||
| GG | > 7 | 71 | 80 | 0.78 (0.49–1.24) | 0.29 | ||
| GT+TT | < 1 | 68 | 63 | 0.89 (0.55–1.44) | 0.63 | ||
| GT+TT | 1–3 | 63 | 70 | 0.72 (0.44–1.17) | 0.18 | ||
| GT+TT | 4–6 | 49 | 67 | 0.63 (0.38–1.05) | 0.07 | ||
| GT+TT | > 7 | 81 | 89 | 0.81 (0.52–1.27) | 0.36 | ||
| rs848 | Overnight meal (times/week) | 1.24 (1.08–1.42) | 0.002 | ||||
| GG | < 1 | 49 | 63 | 1 | |||
| GG | 1–3 | 97 | 120 | 1.07 (0.66–1.72) | 0.79 | ||
| GG | > 3 | 101 | 95 | 1.41 (0.91–2.39) | 0.12 | ||
| GT+TT | < 1 | 54 | 63 | 1.07 (0.62–1.83) | 0.81 | ||
| GT+TT | 1–3 | 93 | 139 | 0.84 (0.52–1.34) | 0.45 | ||
| GT+TT | > 3 | 114 | 85 | 1.82 (1.12–2.96) | 0.02 | ||
| rs1295685 | Allium vegetables (times/week) | 0.92 (0.84–1.00) | 0.06 | ||||
| CC | < 1 | 84 | 67 | 1 | |||
| CC | 1–3 | 58 | 66 | 0.82 (0.50–1.34) | 0.42 | ||
| CC | 4–6 | 34 | 58 | 0.50 (0.29–0.86) | 0.01 | ||
| CC | > 7 | 69 | 79 | 0.76 (0.41–1.21) | 0.24 | ||
| CT+TT | < 1 | 67 | 65 | 0.84 (0.52–1.36) | 0.47 | ||
| CT+TT | 1–3 | 59 | 73 | 0.64 (0.40–1.05) | 0.08 | ||
| CT+TT | 4–6 | 50 | 65 | 0.65 (0.39–1.07) | 0.09 | ||
| CT+TT | > 7 | 79 | 88 | 0.78 (0.50–1.24) | 0.29 | ||
| rs1295685 | Overnight meal (times/week) | 1.21 (1.05–1.39) | 0.008 | ||||
| CC | < 1 | 46 | 63 | 1 | |||
| CC | 1–3 | 96 | 121 | 1.12 (0.69–1.81) | 0.65 | ||
| CC | > 3 | 103 | 88 | 1.72 (1.05–2.81) | 0.03 | ||
| CT+TT | < 1 | 53 | 62 | 1.13 (0.65–1.95) | 0.66 | ||
| CT+TT | 1–3 | 92 | 138 | 0.90 (0.55–1.45) | 0.65 | ||
| CT+TT | > 3 | 110 | 89 | 1.82 (1.16–2.98) | 0.02 | ||
*P value for interaction analysis conducted by multivariate logistic regression.
#Allium vegetables, vegetables in the Allium genus include onions, shallots, leeks and scallions, as well as herbs like garlic and chives.
$Overnight meal, the vegetables, egg, meat that have been cooked and left overninght.
SNP, Single Nucleotide Polymorphism
ORdg, OR for combined effects of dietary factors and genetic factors
ORi, OR for interactive effects of dietary factors and genetic factors