Figure 7. Alpha-mangostin suppresses tumor growth in accordance with activation of ASK1/p38 and caspase cascade in a xenograft model of cervical cancer.

Nude mice (BALB/c nu/nu) were treated with DMSO (vehicle) or α-mangostin (20 or 40 mg/kg) every week after an initial subcutaneous injection of HeLa cells. (A) Representative tumors isolated from mice at 5 weeks after initiation of treatment are shown. (B) Tumor volume at each time interval was measured during treatment. The tumor (C) and body (D) weight of each mouse were measured at the end of the treatment. Expressions of p-ASK1, p-p38, cleaved-PARP, and cleaved-caspase-3 in the tumor mass were examined by IHC staining (E) and by immunoblotting (F). Representative results are shown. **P < 0.01.